Scientist, In Vivo Pharmacology

Boston, Massachusetts, United States | Full-time

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Overview:

The In vivo Scientist position will technically execute and manage in vivo support for pre-clinical biomedical imaging and pathology studies toward pharmaceutical discovery and development. Studies will include rat and mouse biodistribution, disease model development, drug efficacy, and toxicology-like studies in neurology, oncology, and other therapeutic areas. The qualified candidate will manage a team of 3-4 scientists, oversee management of the rodent colony, contribute to study design, develop and implement animal models, and communicate data and project updates. This position will provide an opportunity for growth in leadership skills and exposure to cutting-edge research projects.

Responsibilities

  • Develop pharmacological models and associated techniques in allotted timelines
  • Critically assess draft study protocols for experimental details
  • Required qualifications include, but not limited to:
    • Test article administration (IV, PO, IP, SC, IM)
    • Necropsy / tissue resection
    • Rodent veterinary care and husbandry
    • Biological sampling procedures (blood, urine, and feces)
  • Model development and execution of:
    • Efficacy studies
    • Biodistribution studies
    • Pharmacokinetic studies
    • Toxicokinetic studies
    • Xenograft models
  • Work within IACUC protocols to implement and ensure compliance of animal use protocols and SOPs.
  • Procure animals and manage the colony
  • Work independently and prioritize tasks according to study timelines
  • Communicate details of your work with scientists of all levels
  • Oversee the technical operation of a small species animal care facility (ACF)
  • Train and manage a staff of 3-4 to best allocate resources for study execution, including oversight of husbandry

Qualifications and Skills:

  • Bachelor Degree in Animal Science or a related field
  • 5+ years of experience in the biomedical/pharmaceutical research industry performing responsibilities noted above
  • Ability to multi-task effectively is essential
  • Strong written and oral communication skills
  • Comfort with various computer operating systems and programs
  • Ability to lift 50 pounds

Preferred but not required qualifications:

  • Experience in multiple therapeutic areas
  • Experience managing studies and communicating with multiple teams or departments
  • Knowledge of CRO operations and sponsor interactions
  • Knowledge of the application of radioisotopes in a drug discovery setting
  • Familiarity with small animal imaging modalities
  • Compound handling and formulation
  • Tissue micro-dissection
  • Survival surgery techniques
  • CNS administration of test articles (intrathecal, intracisternal, intraventricular)
  • CSF collection
  • In vitro assay and cell culture applications
  • Knowledge of rare disease and fragile animal models
  • Management experience

What We Offer:

  • Competitive salary
  • 401k with generous matching
  • Flexible vacation policy
  • Catered lunch Wednesdays
  • “First Fridays” – monthly company-wide team updates and happy hour

 

Invicro is an equal opportunities employer and positively encourages applications from suitably qualified and eligible candidates regardless of sex, race, disability, age, sexual orientation, gender reassignment, religion or belief, marital status, or pregnancy and maternity.